Supporting International Women's Day

Mrs Overton supported International Women's Day at the Bristol City Hall on Saturday 2nd March 2019 by discussing Menopause: Medicine, Society, Work and Self.

She was part of an expert panel with Lauren Chiren, Beccy Golding, Isabel de Salis and Daisy Rajput exploring the impact of menopause on women's lives.


Thyroxine treatment for miscarriage trial published

The results of the TABLET trial have been published in the New England Journal of Medicine in March 2019.

The TABLET trial was a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live-birth rates among women who have normal thyroid function with thyroid peroxidase antibodies and a history of miscarriage or infertility. A total of 19,585 women from 49 hospitals in the United Kingdom underwent testing for thyroid peroxidase antibodies and thyroid function.

The results showed that the use of levothyroxine in euthyroid women with thyroid peroxidase antibodies did not result in a higher rate of live births than placebo. (Funded by the United Kingdom National Institute for Health Research; TABLET Current Controlled Trials number, ISRCTN15948785.)

Levothyroxine article in the New England Journal of Medicine

Caroline talks to John Darvall about the menopause

Caroline talks to John Darvall on BBC Radio Bristol on Friday 12 May 2017 about the menopause transition.
Listen to a clip from the programme (90sec, MPEG4).

Fibroid management article in The Practitioner

Read the article: Tailor management to the patient with fibroids (pdf)

Caroline is top 100 researcher

Caroline was awarded top 100 researcher UK with a presentation at BMA House in London in February 2016.

Using HRT to manage the menopause article in The Practitioner

Read the article: Managing debilitating menopausal symptoms (pdf)

NICE Endometriosis guideline published September 2017

After competitive interviews, Caroline was appointed to the position of Chair of the NICE Guideline Committee on the diagnosis and management of Endometriosis. The NICE Endometriosis guideline was published in September 2017 following public and stakeholder consultation.
See the Recommendations on on the NICE website.
See the Full guideline on the NICE website 

Miscarriage research

(PRISM) Progesterone in Spontaneous Miscarriage trial
Mrs Caroline Overton is Primary Investigator for the PRISM trial at St Michael's University Hospital Early Pregnancy Assessment Clinic. PRISM will test the hypothesis that giving progesterone to women with threatened miscarriage in the first 12 weeks of pregnancy, increases the number of live births when compared with placebo. More information about the PRISM trial.

(TABLET) Thyroxine treatment for miscarriage trial

Mrs Caroline Overton is Primary Investigator for the TABLET trial at St Michael's University Hospitals Bristol Early Pregnancy Assessment Clinic.

The TABLET Trial is a large, double blind, placebo controlled trial that will test the hypothesis that in euthyroid women with thyroid peroxidase antibodies, levothyroxine (50mcg, oral, once daily), started before pregnancy and continued to the end of pregnancy, increases live births beyond 34 completed weeks of gestation by at least 10% compared with placebo.

(SOLSTICE) Elagolix research

The SOLSTICE clinical research study is for women who are dealing with endometriosis pain. SOLSTICE is a randomized, placebo-controlled trial to evaluate the safety and effectiveness of Elagolix (an oral Gonadotrophin-releasing hormone antagonist) for moderate to severe endometriosis pain symptoms.

Recruitment opened in February 2014. We have pre-screened 80 women for inclusion into this study. Of these 80, eight women signed consent and entered the wash-out period of the trial. Of these eight women, three patients were randomised into the treatment phase and one of these women has completed the extension study phase.

4 signs of endometriosis women should never ignore

Many women put up with these symptoms for years, not realising the damage they are doing to their health and fertility. Here's your need-to-know guide on the signs of endometriosis. Endometriosis explained video and guide by Caroline.

Early Pregnancy and Emergency Gynaecology course

A two-day course on Early Pregnancy and Emergency Gynaecology was held at the Royal College of Obstetricians & Gynaecologists, Regent's Park, London on Thursday 16th and Friday 17th March 2017.
See details for 2017 course (pdf).
See the details for the 2018 course.

Suffering in silence with endometriosis - OK Magazine

Caroline gives expert advice on suffering in silence with Endometriosis published in OK Magazine for Endometriosis Awareness week 3 March 2015.
Read the article in OK (pdf)

Recovering after keyhole surgery for endometriosis

Caroline advises Mail Online readers about what to do to ensure a good recovery after surgery for endometriosis. Read a copy of the February 2015 article (pdf).

NICE evidence on the diagnosis and management of miscarriage and ectopic pregnancy

In December 2014, Caroline was a member of the Guideline Development Group that provided advice on the diagnosis and management of ectopic pregnancy and miscarriage in early pregnancy.

NICE guidance on miscarriage and ectopic pregnancy

Caroline was a member of the NICE guideline development committee that developed new guidance on miscarriage and ectopic pregnancy. In this clip from national BBC Breakfast she talks about the new guidelines. BBC miscarriage article on BBC Breakfast.

Bladder Endometriosis in Endolink magazine

August 2012

Endolink - Endometriosis UK's magazine - features an article by Caroline on Bladder Endometriosis - a rare but treatable condition. Endolink Bladder Endometriosis article (pdf).

St Michael's gets Endometriosis accreditation

April 2012

St Michael's is fully accredited by the British Society for Gynaecological Endoscopy as an Endometriosis Centre providing excellence in the treatment of endometriosis (accredited centres list).

This is great news for St Michael's and confirms its status as a leading centre.

Caroline contributes to Cosmopolitan article about endometriosis

April 2012

The article describes what endometriosis means to a sufferer, Frances and Caroline explain the condition and comment on the difficulty GPs have in making the diagnosis. Cosmopolitan endometriosis article, April 2012 (pdf)

Secret guide to Women's Health to be repeated

March 2012

Sky Television's 'The secret guide to Women's Health' series is to be repeated on the Sky living channel. The ten-part series aims to raise awareness of women's health issues - many of which are often considered taboo. Each programme featured two women who came into the studio and shared their experience of a particular condition. Caroline was nominated by Endometriosis UK as an expert on Endometriosis and involved in the studio discussion with host Coleen Nolan and resident GP, Dr Rosemary Leonard.

Caroline is NHS Choices expert

November 2011

The new NHS Choices video on endometriosis features Caroline as the endometriosis expert. The video outlines the symptoms and treatment options, who is affected by it and how to cope with the pain. NHS Choices endometrosis video.